A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20016 |
| Swiss-prot Accession number | Q28928 (Sequence in FASTA format) |
| Description | Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R)(Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor)(Fragment). |
| Source organism | Papio hamadryas (Hamadryas baboon) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. |
| Protein Length | 126 Amino acids |
| Molecular weight | 14217 |
| Domain Name | N/A |
| References | 1 PubMed abstract 8625902 2 PubMed abstract 8625902 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20932 |
| Swiss-prot Accession number | Q864J2 (Sequence in FASTA format) |
| Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R). |
| Source organism | Papio hamadryas (Hamadryas baboon) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). |
| Protein Length | 317 Amino acids |
| Molecular weight | 34751 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 12687585 2 PubMed abstract 12687585 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 21215 |
| Swiss-prot Accession number | O97960 (Sequence in FASTA format) |
| Description | RecName: Androgen receptor;Alternative Name: Dihydrotestosterone receptor;Alternative Name: Nuclear receptor subfamily 3 group C member 4; |
| Source organism | Papio hamadryas (Hamadryas baboon) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-510 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). |
| Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 (By similarity). |
| Protein Length | 895 Amino acids |
| Molecular weight | 96479 |
| Domain Name | Androgen_recep Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9732460 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |